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Low-avidity T cells drive endogenous tumor immunity in mice and humans

9 Jan 2025

Abstract excerpt

T cells recognize neoepitope peptide-major histocompatibility complex class I on cancer cells. The strength (or avidity) of the T cell receptor–peptide-major histocompatibility complex class I interaction is a critical variable in immune control of cancers. Here, we analyze neoepitope-specific CD8 cells of distinct avidities and show that low-avidity T cells are the sole mediators of cancer control in mice and...

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PMID: 39789375
DOI: 10.1038/s41590-024-02044-z

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