Article

Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivity

2023-09-03

Abstract excerpt

Ovarian cancer (OvCa) is the most lethal of the gynecologic malignancies. Immune checkpoint inhibitors, which have revolutionized the treatment of multiple malignancies, have had limited efficacy in OvCa patients. Here, using syngeneic OvCa models and genetic and pharmacologic perturbations, we discovered that losartan – a widely prescribed anti-hypertensive drug – exhibits dual effects on both the tumor microenvi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa1485d3-03b8-566b-bacd-1bbe96182848
DOI: 10.1101/2023.08.31.555783

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivityDOI 10.1101/2023.08.31.555783Read

ANGPTL4 regulates ovarian cancer progression by activating the ERK1/2 pathwaySemantic proximity Read

IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancerSemantic proximity Read

Multicompartmentalized Microvascularized Tumor-on-a-Chip to Study Tumor-Stroma Interactions and Drug Resistance in Ovarian CancerSemantic proximity Read

Multicompartmentalized microvascularized tumor-on-a-chip to study tumor-stroma interactions and drug resistance in ovarian cancerSemantic proximity Read

Revisiting ovarian cancer microenvironment: a friend or a foe?Semantic proximity Read

An <i>In Vitro</i> Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates <i>In Vivo</i> Drug ResponsesSemantic proximity Read

Using targeted therapy to promote a pro-inflammatory tumour microenvironment and anti-tumour immune response in high grade serous ovarian cancerSemantic proximity Read

Zebrafish avatars: towards functional precision medicine in low-grade serous ovarian cancerSemantic proximity Read

ANGPT1 as a Key Regulator in Tumor Microenvironment and Immunotherapy Response Across Multiple Cancers: A Pan-cancer AnalysisSemantic proximity Read

Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemnessSemantic proximity Read

Tumorigenicity of Ascites-Derived Tumor Cells: Insights Into the Molecular Mechanisms of Ovarian Cancer Progression and Therapy ResistanceSemantic proximity Read

ANGPTL4-ETV5-CDH5 Signaling Axis: A Novel Pathway Driving Metastasis in Ovarian CancerSemantic proximity Read