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ANGPTL4 regulates ovarian cancer progression by activating the ERK1/2 pathway

4 Feb 2024

Abstract excerpt

BACKGROUND: Ovarian cancer (OC) has the highest mortality rate among all gynecological malignancies. A hypoxic microenvironment is a common feature of solid tumors, including ovarian cancer, and an important driving factor of tumor cell survival and chemo- and radiotherapy resistance. Previous research identified the hypoxia-associated gene angiopoietin-like 4 (ANGPTL4) as both a pro-angiogenic and pro-metastatic...

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PMID: 38311733
DOI: 10.1186/s12935-024-03246-z

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