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Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

28 May 2024

Abstract excerpt

In ovarian tumors, the omental microenvironment profoundly influences the behavior of cancer cells and sustains the acquisition of stem-like traits, with major impacts on tumor aggressiveness and relapse. Here, we leverage a patient-derived platform of organotypic cultures to study the crosstalk between the tumor microenvironment and ovarian cancer stem cells. We discovered that the pro-tumorigenic transcription...

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PMID: 38806454
DOI: 10.1038/s41419-024-06767-7

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