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IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancer

2023-09-26

Abstract excerpt

Advanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ∼25% surviving beyond 5 years. Evidence suggests that cancer stem cells (CSCs) contribute to acquired chemoresistance and tumor recurrence. Here, we show that IRAK1 is upregulated in EOC tissues, and enhanced expression correlates with poorer overall survival. IRAK1 and BRCA1/2 mutation status are mutually exclusive. Moreover, l...

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Identifiers and source

Literature Corpus work
b651ce3c-b20e-5377-8fd2-4c69eda10a4b
DOI
10.1101/2023.09.25.559366
Open publication

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IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancerDOI 10.1101/2023.09.25.559366
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