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Article

Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes.

Cell transplantation - 1 May 2018

Mattiucci Domenico, Maurizi Giulia, Leoni Pietro, Poloni Antonella

Abstract excerpt

Hematopoietic stem and progenitor cells reside within the bone marrow (BM) microenvironment. By a well-balanced interplay between self-renewal and differentiation, they ensure a lifelong supply of mature blood cells. Physiologically, multiple different cell types contribute to the regulation of stem and progenitor cells in the BM microenvironment by cell-extrinsic and cell-intrinsic mechanisms. During the last...

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Identifiers

PMID: 29682980
DOI: 10.1177/0963689717745890
PMCID: PMC6047275

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