Immune Dysregulation and Recurring Mutations in Myelodysplastic Syndromes Pathogenesis.

Abstract excerpt

Myelodysplastic syndromes (MDS) are clonal stem cell malignancies characterized by ineffective hematopoiesis leading to peripheral cytopenias and variable risk of progression to acute myeloid leukemia. Inflammation is associated with MDS pathogenesis. Several cytokines, reactive species of oxygen/nitrogen and growth factors are directly or indirectly involved in dysfunction of the MDS bone marrow (BM)...

Topics

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• Bone Marrow
• Hematopoiesis
• Leukemia, Myeloid, Acute
• Mutation
• Myelodysplastic Syndromes