Article
Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.
Nature communications - 27 Jun 2018
Lu I-Ling, Chen Chien, Tung Chien-Yi, Chen Hsin-Hung, Pan Jia-Ping, Chang Chia-Hsiang, Cheng Jia-Shing, Chen Yi-An, Wang Chun-Hung, Huang Chia-Wei, Kang Yi-Ning, Chang Hsin-Yun, Li Lei-Li, Chang Kai-Ping, Shih Yang-Hsin, Lin Chi-Hung, Kwan Shang-Yeong, Tsai Jin-Wu
Abstract excerpt
Mutations in genes involved in the production, migration, or differentiation of cortical neurons often lead to malformations of cortical development (MCDs). However, many genetic mutations involved in MCD pathogenesis remain unidentified. Here we developed a genetic screening paradigm based on transposon-mediated somatic mutagenesis by in utero electroporation and the inability of mutant neuronal precursors to...
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