Article

Brain size links neurodevelopment to neurodegeneration in Parkinson's disease

2025-12-11

Abstract excerpt

Genetic studies have advanced our understanding of Parkinson's disease (PD) pathogenesis, establishing a role for autophagy and lysosomal dysfunction. However, how genetic risk translates into neuronal vulnerability remains mostly unknown. Using recent genome-wide association studies and neuroimaging data from UK Biobank, we show that higher polygenic risk score of PD correlates with greater cortical surface area,...

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Literature Corpus work: a933c8b4-18bb-56cf-bbe0-767aa96ea69c
DOI: 10.64898/2025.12.09.25341901

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