Article

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate

2025-02-21

Abstract excerpt

<h4>Summary</h4> Damaged mitochondria can be cleared from the cell by mitophagy, using a pathway formed by the recessive Parkinson’s disease genes PINK1 and Parkin. How mitochondrial damage is sensed by the PINK1-Parkin pathway, however, remains uncertain. Here, using a Parkin substrate-based reporter in genome-wide screens, we identified that diverse forms of mitochondrial damage converge on loss of mitochondria...

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Literature Corpus work: a8b3327c-4733-5b3e-a22f-311e329ecbed
DOI: 10.1101/2025.02.19.639160

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