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Genome-wide high-density CRISPR interference screens reveal condition-specific metabolic vulnerabilities in <i>Pseudomonas aeruginosa</i> PAO1

2025-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Pseudomonas aeruginosa is a metabolically versatile opportunistic human pathogen. It causes acute and chronic infections and is notorious for its multidrug resistance and tolerance. To systematically uncover genetic vulnerabilities that could be exploited as therapeutic targets, we present a portable high-density CRISPR interference (CRISPRi) library comprising >80’000 single-guide RNAs (sgRNAs)...

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Literature Corpus work
e76acabd-8f56-5f74-80d4-86acfa4c607a
DOI
10.1101/2025.08.12.669819
Open publication

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Genome-wide high-density CRISPR interference screens reveal condition-specific metabolic vulnerabilities in <i>Pseudomonas aeruginosa</i> PAO1DOI 10.1101/2025.08.12.669819
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