Back to search

Article

Genome-scale modeling of <i>Pseudomonas aeruginosa</i> PA14 unveils its broad metabolic capabilities and role of metabolism in drug potentiation

2021-04-15

Abstract excerpt

P. aeruginosa is an opportunistic human pathogen that is one of the leading causes of hospital-acquired infections. We have developed an updated genome-scale model (GEM) of Pseudomonas aeruginosa PA14 for systems-study of the pathogen. We used both automated and semi-manual approaches to reconstruct and curate the model. After an extensive literature research, we added organism-specific reactions (e.g., phenazine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
69f31597-3a22-5602-aa06-5b30c774af7e
DOI
10.1101/2021.04.15.439930
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genome-scale modeling of <i>Pseudomonas aeruginosa</i> PA14 unveils its broad metabolic capabilities and role of metabolism in drug potentiationDOI 10.1101/2021.04.15.439930
Predicting strain-specific metabolic capabilities in the Genus <i>Pseudomonas</i> using a Flux-to-AI approach unravels hidden cell envelope propertiesSemantic proximity
Model-driven characterization of functional diversity of <i>Pseudomonas aeruginosa</i> clinical isolates with broadly representative phenotypesSemantic proximity
Systems-wide dissection of organic acid assimilation in <i>Pseudomonas aeruginosa</i> reveals a novel path to underground metabolismSemantic proximity
Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis.Semantic proximity
A validated pangenome-scale metabolic model for the <i>Klebsiella pneumoniae</i> species complexSemantic proximity
Model-driven characterization of functional diversity of Pseudomonas aeruginosa clinical isolates with broadly representative phenotypes.Semantic proximity
Global stress response in <i>Pseudomonas aeruginosa</i> upon malonate utilizationSemantic proximity
An integrated computational and experimental study to elucidate <i>Staphylococcus aureus</i> metabolismSemantic proximity
<i>Pseudomonas aeruginosa</i> core metabolism exerts a widespread growth-independent control on virulenceSemantic proximity
Metabolism-Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing.Semantic proximity
Pseudomonas aeruginosa core metabolism exerts a widespread growth-independent control on virulence.Semantic proximity
Genome-scale metabolic model atlas of the zoonotic pathogen <i>Streptococcus suis</i>Semantic proximity
Select a neighboring publication to make it the new centre.