Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain-of-Function Mutations in Acid Stress Response (evgS) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate.

Antimicrobial agents and chemotherapy - 17 Feb 2021

Zeng Jie, Wu Liwen, Liu Zhou, Lv Yihua, Feng Jinzhi, Wang Weijie, Xue Yunxin, Wang Dai, Li Jiabin, Drlica Karl, Zhao Xilin

Abstract excerpt

Widespread antimicrobial resistance encourages repurposing/refining of nonantimicrobial drugs for antimicrobial indications. Gallium nitrate (GaNt), an FDA-approved medication for cancer-related hypercalcemia, recently showed good activity against several clinically significant bacteria. However, the mechanism of GaNt antibacterial action is still poorly understood. In the present work, resistant and tolerant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Anti-Infective Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Gain of Function Mutation

Share to Mutation

Share to Protein Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 33257448
DOI: 10.1128/AAC.01595-20
PMCID: PMC8092542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gain-of-Function Mutations in Acid Stress Response (evgS) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate.PMID 33257448Read ↗

Opposing roles for iron transport systems in gallium tolerance in extraintestinal pathogenic <i>Escherichia coli</i>Semantic proximity Read ↗

Genome-wide CRISPRi-seq identified ferredoxin-NADP reductase FprB as a synergistic target for gallium therapy in <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Genome-wide CRISPRi-seq identified ferredoxin-NADP reductase FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosaSemantic proximity Read ↗

Antibacterial activity of gallium nitrate against polymyxin-resistant Klebsiella pneumoniae strains.Semantic proximity Read ↗

Glyphosate, a herbicide, and fosfomycin, an antibiotic in clinical use- evidence of common selectable genotypesSemantic proximity Read ↗

Implementation of Three Gallium-Based Complexes in the “Trojan Horse” Antibacterial Strategy against A. baumannii: A DFT ApproachSemantic proximity Read ↗

Identification of glyoxalase A in group B Streptococcus and its contribution to methylglyoxal tolerance and virulenceSemantic proximity Read ↗

Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.Semantic proximity Read ↗

Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen <i>Vibrio cholerae</i>Semantic proximity Read ↗

Oxidative stress facilitates a diverse adaptive response in bacteriaSemantic proximity Read ↗

Genome-Wide Screens Identify Genes Responsible for Intrinsic Boric Acid Resistance in Escherichia coli.Semantic proximity Read ↗

Bright luminescence of Vibrio fischeri aconitase mutants reveals a connection between citrate and the Gac/Csr regulatory system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.