Article

Syncytia Formation Promotes Virus Resistance to Interferon and Neutralizing Antibodies

2024-09-20

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2, like many viruses, generates syncytia. Using SARS-CoV-2 and Spike (S) expressing recombinant vesicular stomatitis and influenza A viruses, we show that S-mediated syncytia formation provides resistance to interferons in cultured cells, human small airway-derived air-liquid interface cultures and hACE2 transgenic mice. Amino acid substitutions that modulate fusogenicity in De...

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Literature Corpus work: f9a422fb-38d5-52ce-90ef-5d732436cb40
DOI: 10.21203/rs.3.rs-3846435/v1

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