Article

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

2021-01-22

Abstract excerpt

Virus propagation methods generally use transformed cell lines to grow viruses from clinical specimens, which may force viruses to rapidly adapt to cell culture conditions, a process facilitated by high viral mutation rates. Upon propagation in VeroE6 cells, SARS-CoV-2 may mutate or delete the multibasic cleavage site (MBCS) in the spike protein that facilitates serine protease-mediated entry into human airway cel...

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Literature Corpus work: 34a63a4f-3fb2-51df-90ea-e2126dbad86b
DOI: 10.1101/2021.01.22.427802

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