Article
SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.
The EMBO journal - 15 Dec 2021
Rajah Maaran Michael, Hubert Mathieu, Bishop Elodie, Saunders Nell, Robinot Remy, Grzelak Ludivine, Planas Delphine, Dufloo Jérémy, Gellenoncourt Stacy, Bongers Alice, Zivaljic Marija, Planchais Cyril, Guivel-Benhassine Florence, Porrot Françoise, Mouquet Hugo, Chakrabarti Lisa A, Buchrieser Julian, Schwartz Olivier
Abstract excerpt
Severe COVID-19 is characterized by lung abnormalities, including the presence of syncytial pneumocytes. Syncytia form when SARS-CoV-2 spike protein expressed on the surface of infected cells interacts with the ACE2 receptor on neighboring cells. The syncytia forming potential of spike variant proteins remain poorly characterized. Here, we first assessed Alpha (B.1.1.7) and Beta (B.1.351) spread and fusion in...
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