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Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

6 Aug 2020

Abstract excerpt

SARS-CoV-2, a β-coronavirus, has rapidly spread across the world, highlighting its high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly understood. Here, we characterize the replication dynamics, cell tropism and morphogenesis of SARS-CoV-2 in organotypic human airway epithelial (HAE) cultures. SARS-CoV-2 replicates efficiently and infects both ciliated and secretory cells in HAE...

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PMID: 32764693
DOI: 10.1038/s41467-020-17796-z

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