Back to search

Article

Viral Syncytia Evolve to Resist Interferon

2023-12-13

Abstract excerpt

SARS-CoV-2, like many viruses, generates syncytia but the role of syncytia formation in viral evolution remains unknown. Using SARS-CoV-2 and SARS-CoV-2 Spike (S) replacement vesicular stomatitis (VSV), we show that S-mediated syncytia impair the antiviral effects of interferons in cultured cells, human lung cell cultures, and hACE2 transgenic mice. Amino acid substitutions that modulate syncytia formation in Delt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b7f65dcc-357a-534c-88ba-bdd154d293e3
DOI
10.1101/2023.12.12.571262
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Viral Syncytia Evolve to Resist InterferonDOI 10.1101/2023.12.12.571262
Syncytia Formation Promotes Virus Resistance to Interferon and Neutralizing AntibodiesSemantic proximity
SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralizationSemantic proximity
Convergent Evolution and Host-Limiting Impacts of SARS-CoV-2 Revealed by Cellular Experiments.Semantic proximity
Interferon Resistance of Emerging SARS-CoV-2 VariantsSemantic proximity
SARS-CoV-2 evolution influences GBP and IFITM sensitivitySemantic proximity
Syncytia Formation in the Pathogenesis of SARS-CoV-2 Infection: Lessons from Viral Infections.Semantic proximity
Interferon resistance of emerging SARS-CoV-2 variantsSemantic proximity
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte eliminationSemantic proximity
SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.Semantic proximity
Cell–cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA virusesSemantic proximity
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell SignalingSemantic proximity
Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53Semantic proximity
Select a neighboring publication to make it the new centre.