Article

Sex- and age-dependent effects of locus coeruleus-originated tau dysfunction on olfaction and neurophysiology in rats

2023-11-05

Abstract excerpt

Braak and colleagues (2011) described human pretangle stages of abnormal tau protein originating in the locus coeruleus (LC) of young adults (Braak’s Stages a-c, 1a-b), decades prior to the neurofibrillary tangle stages observed in Alzheimer’s disease. To capture the features of LC-originated pretangle tau stages, we used a rat model where male and female TH-Cre +/- rats received bilateral LC infusions of a hyper...

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Literature Corpus work: 7e07fe18-8756-5221-a2bb-487fa77ef52c
DOI: 10.1101/2023.11.05.565692

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