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Impact of early locus coeruleus lesions in the TgF344 Alzheimer’s disease rat model

2025-11-10

Abstract excerpt

<h4>INTRODUCTION</h4> In murine models of Alzheimer’s disease (AD), lesioning the locus coeruleus-norepinephrine (LC-NE) system with DSP-4 exacerbates AD-like neuropathology and cognitive impairment. However, the impact of LC lesions during prodromal stages is poorly characterized. <h4>METHODS</h4> TgF344-AD and wild-type rats received monthly injections of DSP-4 or saline from 1-5 months of age, a time point pr...

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Literature Corpus work
01d30255-781c-5964-8c15-d1549600a954
DOI
10.1101/2025.11.09.687363
Open publication

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