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Exploiting the homologous recombination DNA repair network for targeted cancer therapy

27 Nov 2010

Abstract excerpt

Genomic instability is a characteristic of cancer cells. In order to maintain genomic integrity, cells have evolved a complex DNA repair system to detect, signal and repair a diversity of DNA lesions. Homologous recombination (HR)-mediated DNA repair represents an error-free repair mechanism to maintain genomic integrity and ensure high-fidelity transmission of genetic information. Deficiencies in HR repair are...

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PMID: 21603316
DOI: 10.5306/wjco.v2.i2.73

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