Article

Contractility of cardiac and skeletal muscle tissue increases with environmental stiffness

2024-02-24

Abstract excerpt

The mechanical interplay between contractility and mechanosensing in striated muscles is of fundamental importance for tissue morphogenesis, load adaptation, and disease progression, but remains poorly understood. In this study, we investigate the dependence of contractile force generation of cardiac and skeletal muscle on environmental stiffness. Using in vitro engineered muscle micro-tissues that are attached t...

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Literature Corpus work: f9721cc3-3e06-50e0-8e0e-778cb912d0d2
DOI: 10.1101/2024.02.23.581737

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