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Article

Force-sensing protein expression in response to cardiovascular mechanotransduction

31 Oct 2024

Abstract excerpt

Force-sensing biophysical cues in microenvironment, including extracellular matrix performances, stretch-mediated mechanics, shear stress and flow-induced hemodynamics, have a significant influence in regulating vascular morphogenesis and cardiac remodeling by mechanotransduction. Once cells perceive these extracellular mechanical stimuli, Piezo activation promotes calcium influx by forming...

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PMID: 39481337
DOI: 10.1016/j.ebiom.2024.105412

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