Article
Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis
31 Jul 2025
Abstract excerpt
Colorectal cancer, a leading cause of global cancer-related morbidity and mortality, poses a significant challenge with its incidence rising. 5-fluorouracil (5-FU), a key chemotherapy agent, faces the challenge of drug resistance. Clock genes, which regulate circadian rhythms, are linked to tumor occurrence, progression, and treatment responses, and are often abnormally expressed in many tumors. Ferroptosis, a...
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