Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression

Abstract excerpt

Abstract Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m 6 A) is the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, the crucial role of m 6 A modification in regulating ferroptosis during colorectal cancer (CRC) tumorigenesis remains elusive....

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