Article

Type I Interferon production in myeloid cells is regulated by factors independent of <i>Ptpn22</i>

2025-03-25

Abstract excerpt

<h4>ABSTRACT</h4> The immune regulatory gene PTPN22 is expressed in all immune cells and encodes Lyp in humans and the ortholog PEP in mice. The PTPN22 alternative allele, 1858C>T, is expressed in 5-15% of the North American population and is strongly associated with the development of autoimmune disease while simultaneously capable of providing protection during virus infection and cancer. In murine models, si...

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Literature Corpus work: f9546de5-5d1c-5d43-b33f-1409e2706285
DOI: 10.1101/2025.03.20.644450

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