CRISPR-HAWK: Haplotype- and Variant-Aware Guide Design Toolkit for CRISPR-Cas

Abstract excerpt

<h4>Motivation</h4> Current CRISPR guide RNA design tools rely on reference genomes, overlooking how genetic variation impacts editing outcomes. As genome editing advances toward clinical applications, incorporating population diversity becomes essential for ensuring therapeutic efficacy across diverse populations. <h4>Results</h4> We present CRISPR-HAWK, a framework integrating individual- and population-scale...

Topics

Open a Topic to create a Post that cites this publication.

• CRISPR-Cas Systems
• Endonucleases
• Gene Editing
• Gene Targeting
• Genetic Loci
• Genetic Variation
• Principal Component Analysis
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

f9453045-d101-54d0-8d38-e7faaca2757d

DOI

10.64898/2025.12.27.696698