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EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing

2026-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Allele-specific CRISPR/Cas editing is a powerful tool with great potential for treating genetic diseases and for uncovering the effects of allelic diversity. By targeting commonly inherited single nucleotide polymorphisms (SNPs), a small number of gRNAs can treat many more individuals than targeting rare disease mutations. However, current tools for identifying common targetable variants and gen...

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Literature Corpus work
cf5078a9-9a37-5c72-b0f4-365b02bfb11d
DOI
10.64898/2026.07.23.739930
Open publication

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EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific EditingDOI 10.64898/2026.07.23.739930
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