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Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes

11 Feb 2020

Abstract excerpt

Cohesin is essential for genome folding and inheritance. In somatic cells, these functions are both mediated by Scc1-cohesin, which in mitosis is released from chromosomes by Wapl and separase. In mammalian oocytes, cohesion is mediated by Rec8-cohesin. Scc1 is expressed but neither required nor sufficient for cohesion, and its function remains unknown. Likewise, it is unknown whether Wapl regulates one or both...

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PMID: 32328639
DOI: 10.1083/jcb.201906100

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