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Single‐oocyte transcriptome analysis reveals aging‐associated effects influenced by life stage and calorie restriction

10 Jul 2021

Abstract excerpt

Chromosome segregation errors in oocytes lead to the production of aneuploid eggs, which are the leading cause of pregnancy loss and of several congenital diseases such as Down syndrome. The frequency of chromosome segregation errors in oocytes increases with maternal age, especially at a late stage of reproductive life. How aging at various life stages affects oocytes differently remains poorly understood. In...

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PMID: 34245092
DOI: 10.1111/acel.13428

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