Article

Cryo-ET distinguishes platelets during pre-acute myeloid leukemia from steady state hematopoiesis

2021-10-18

Abstract excerpt

Early diagnosis of acute myeloid leukemia (AML) in the pre-leukemic stage remains a clinical challenge, as pre-leukemic patients show no symptoms, lacking any known morphological or numerical abnormalities in blood cells. Here, we demonstrate that platelets with structurally abnormal mitochondria emerge at the pre-leukemic phase of AML, preceding detectable changes in blood cell counts or detection of leukemic bla...

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Literature Corpus work: f943d2fb-6919-56c5-ac21-9d2e152ac501
DOI: 10.1101/2021.10.18.464863

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