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The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia

4 Feb 2025

Abstract excerpt

Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T-ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are...

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PMID: 39905687
DOI: 10.1080/15384047.2025.2460252

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