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Mitochondria in human acute myeloid leukemia cell lines have ultrastructural alterations linked to deregulation of their respiratory profiles.

Experimental hematology - 1 Jun 2021

Mondet Julie, Lo Presti Caroline, Chevalier Simon, Bertrand Anne, Tondeur Sylvie, Blanchet Sandrine, Mc Leer Anne, Pernet-Gallay Karin, Mossuz Pascal

Abstract excerpt

Mitochondria not only are essential for cell metabolism and energy supply but are also engaged in calcium homeostasis and reactive oxygen species generation and play a key role in apoptosis. As a consequence, functional mitochondrial disorders are involved in many human cancers including acute myeloid leukemia (AML). However, very few data are available on the deregulation of their number and/or shape in leukemic...

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PMID: 33689800
DOI: 10.1016/j.exphem.2021.03.001

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