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COVID-19 concerns aggregate around platelets

10 Sept 2020

Abstract excerpt

LSPCs to nonapoptotic, iron-dependent cell death via ferroptosis. Indeed, ferroptosis inhibition functionally rescued Aldh3A2 loss. Conversely, genetic and pharmacologic inhibition of ferroptosis inhibitory glutathione peroxidase 4 (GPX4) and cytotoxic therapy triggered increased elimination of Aldh3a2-deficient LSPCs and extended AML-free survival in vivo compared with aberrant stem cells expressing the...

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PMID: 32957116
DOI: 10.1182/blood.2020007805

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