Article

Exacerbation of mitochondrial fission in human CD34 <sup>+</sup> cells halts erythropoiesis and hemoglobin biosynthesis

2020-08-02

Abstract excerpt

Erythropoiesis is the most powerful cellular differentiation and proliferation system, with a production of 10 11 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and mature into erythrocytes. During erythropoiesis, mitochondria are reprogrammed to drive the differentiation process before finally being eliminated by mitophagy. In eryt...

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Literature Corpus work: 848f1b51-2e2c-5cfc-8d61-099a8e3ba61d
DOI: 10.1101/2020.07.31.230961

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