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Hematopoietic stem cell fate through metabolic control

25 May 2018

Abstract excerpt

Hematopoietic stem cells maintain a quiescent state in the bone marrow to preserve their self-renewal capacity, but also undergo cell divisions as required. Organelles such as the mitochondria sustain cumulative damage during these cell divisions and this damage may eventually compromise the cells' self-renewal capacity. Hematopoietic stem cell divisions result in either self-renewal or differentiation, with the...

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PMID: 29807063
DOI: 10.1016/j.exphem.2018.05.005

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