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The IRE1α-endonuclease regulates PD-1 expression through a novel XBP1/miRNA-34a axis within Natural Killer cells

2023-02-27

Abstract excerpt

Activation of the IRE1α-endonuclease is critical for Natural Killer (NK)-cell function. We describe a novel regulatory role for IRE1α-endonuclease in fine-tuning NK-cell effector functions through an inter-connected activation of the transcription factor XBP1s and inhibition of microRNA-34a-5p (miR-34a-5p) to modulate PD-1 immune checkpoint expression. NK-cells, when exposed to cancer cells, activate IRE1α-endonuc...

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Identifiers and source

Literature Corpus work
f9089d19-2773-552d-a51d-a13ed1c213bd
DOI
10.1101/2023.02.26.530063
Open publication

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The IRE1α-endonuclease regulates PD-1 expression through a novel XBP1/miRNA-34a axis within Natural Killer cellsDOI 10.1101/2023.02.26.530063
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