Article

Noncanonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α promotes cancer-cell survival

2021-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Eukaryotic IRE1 mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates the transcription factor XBP1s by intron excision between similar RNA stem-loop endomotifs, and depletes select cellular mRNAs through regulated IRE1-dependent d...

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Literature Corpus work: 5961c046-8925-5ed7-be0e-e5e72e1ffa06
DOI: 10.1101/2021.03.16.435520

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