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A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

2 Nov 2015

Abstract excerpt

Recognition and elimination of tumor cells by the immune system is crucial for limiting tumor growth. Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on cancer cell lines. However, the molecular mechanisms driving NKG2D ligand expression on tumor cells are not well defined. Using a forward genetic screen in a...

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PMID: 26565589
DOI: 10.7554/elife.08474

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