Article

The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid Leukemias

2024-02-21

Abstract excerpt

Natural Killer (NK) cells play a pivotal role in mounting an anti-cancer immune response. Patients with diminished NK cells number and activity face less favorable prognosis. Promising therapeutic strategies include the adoptive transfer of NK cells or the reactivation of patients’ own NK cells. TAK-981, a first-in-class inhibitor of SUMOylation undergoing phase I/II clinical trials for cancer, is emerging as an i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b440b31-31d7-5ee5-a8ce-bc62c969d7f5
DOI: 10.1101/2024.02.19.580882

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid LeukemiasDOI 10.1101/2024.02.19.580882Read

Adoptive NK cell therapy in AML: progress and challengesSemantic proximity Read

<i>Bona fide</i> cytotoxic iNKT cells with superior antitumour responses identified in mice and humansSemantic proximity Read

High-Risk Leukemia: Past, Present, and Future Role of NK CellsSemantic proximity Read

Structural insights into activation of antiviral <scp>NK</scp> cell responsesSemantic proximity Read

Cytokine-induced Expandable Memory NK Cells with Significant Metabolic, Epigenetic Remodeling, and Persistence PropertiesSemantic proximity Read

IKAROS and AIOLOS activate AP-1 transcriptional complexes and are essential for natural killer cell developmentSemantic proximity Read

IL-1R8 : a novel checkpoint regulating anti-tumor and anti-viral activity of NK cellsSemantic proximity Read

SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor InfiltrationSemantic proximity Read

An integrated multi-omics investigation of W-NK1, a cytokine-primed non-engineered natural killer cell therapy productSemantic proximity Read

Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulationSemantic proximity Read

STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in <i>TP53</i> -mutated AMLSemantic proximity Read

Dark NKnight rising: a current perspective on NK cell and CAR-NK cell therapySemantic proximity Read