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Article

IRE1α Promotes Zika Virus Infection via XBP1

3 Mar 2020

Abstract excerpt

Zika virus (ZIKV) is an emergent member of the Flaviviridae family which causes severe congenital defects and other major sequelae, but the cellular processes that support ZIKV replication are incompletely understood. Related flaviviruses use the endoplasmic reticulum (ER) as a membranous platform for viral replication and induce ER stress during infection. Our data suggest that ZIKV activates IRE1α, a component...

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PMID: 32138181
DOI: 10.3390/v12030278

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