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Article

The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice

26 Oct 2023

Abstract excerpt

ABSTRACT Post-transplant lymphoproliferative disorders (PTLD) are a group of heterogeneous diseases originating in conditions of immune deficiency, whose main driver is considered to be Epstein-Barr virus (EBV). Here, we explored the role of IRE1alpha/XBP1s axis in EBV-driven lymphomagenesis in an NOD SCID gamma mouse model, as these animals develop malignancies that closely resemble PTLD when engrafted with...

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PMID: 37882554
DOI: 10.1128/spectrum.02636-23

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