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Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: <i>DTNB</i> and <i>DLG2</i>

2021-06-12

Abstract excerpt

Alzheimer’s disease (AD) is a genetically complex disease for which roughly 30 genes have been identified via genome-wide association studies. We attempted to identify rare variants (minor allele frequency <0.01) associated with AD in a region-based, whole genome sequencing (WGS) association study (GSAS) of two independent AD family datasets (NIMH/NIA; 2247 individuals; 605 families). Employing a sliding window ap...

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Literature Corpus work
f8dce729-9928-512a-8d6c-f75b7334ed26
DOI
10.1101/2021.06.09.21258576
Open publication

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Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: <i>DTNB</i> and <i>DLG2</i>DOI 10.1101/2021.06.09.21258576
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