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Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development

2020-11-04

Abstract excerpt

<h4>INTRODUCTION</h4> Genome-wide association studies have led to numerous genetic loci associated with Alzheimer’s disease (AD). Whole-genome sequencing (WGS) now permit genome-wide analyses to identify rare variants contributing to AD risk. <h4>METHODS</h4> We performed single-variant and spatial clustering-based testing on rare variants (minor allele frequency ≤1%) in a family-based WGS-based association study...

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Literature Corpus work: 9fc98c4c-c843-5500-824a-25f19f8d3ddb
DOI: 10.1101/2020.11.03.20225540

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