Article
Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2024
Wang Yanbing, Sarnowski Chloé, Lin Honghuang, Pitsillides Achilleas N, Heard-Costa Nancy L, Choi Seung Hoan, Wang Dongyu, Bis Joshua C, Blue Elizabeth E, Boerwinkle Eric, De Jager Philip L, Fornage Myriam, Wijsman Ellen M, Seshadri Sudha, Dupuis Josée, Peloso Gina M, DeStefano Anita L
Abstract excerpt
INTRODUCTION: Genome-wide association studies (GWAS) have identified loci associated with Alzheimer's disease (AD) but did not identify specific causal genes or variants within those loci. Analysis of whole genome sequence (WGS) data, which interrogates the entire genome and captures rare variations, may identify causal variants within GWAS loci. METHODS: We performed single common variant association analysis...
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