Article
Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
Molecular psychiatry - 1 Apr 2022
Prokopenko Dmitry, Lee Sanghun, Hecker Julian, Mullin Kristina, Morgan Sarah, Katsumata Yuriko, Weiner Michael W, Fardo David W, Laird Nan, Bertram Lars, Hide Winston, Lange Christoph, Tanzi Rudolph E
Abstract excerpt
Alzheimer's disease (AD) is a genetically complex disease for which nearly 40 loci have now been identified via genome-wide association studies (GWAS). We attempted to identify groups of rare variants (alternate allele frequency <0.01) associated with AD in a region-based, whole-genome sequencing (WGS) association study (rvGWAS) of two independent AD family datasets (NIMH/NIA; 2247 individuals; 605 families)....
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