Article

Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer’s disease and related dementias and Parkinson’s disease and related disorders

2026-03-04

Abstract excerpt

Alzheimer’s disease and related dementias (ADRD) 1 and Parkinson’s disease and related disorders (PDRD) 2 have substantial genetic contributions, yet the role of rare damaging coding variants remains incompletely characterized at population scale 3–6 . We performed gene-burden testing of loss-of-function and deleterious missense variants in biobanks and disease-focused sequencing cohorts, using calibrated proxy...

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Literature Corpus work: 5869d6a1-57ff-5615-a1b4-9585587afa93
DOI: 10.64898/2026.03.03.26347540

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