Article
Elucidation of the effects of hypoxia on DNA repair machinery in brain tumour cells
2018-01-01
Abstract excerpt
Glioblastoma (GBM) and Medulloblastoma (MB) are the most common brain tumours of adults and children respectively. These tumours are hypoxic as their oxygen levels are lower than the physiological 5-8% O2 found in the brain. Tumour hypoxia can promote tumour cell invasion, increase metastatic potential and leads to resistance to conventional cancer therapies. Chemotherapeutic agents and irradiation induce excessiv...
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Identifiers and source
- Literature Corpus work
- f8d3afb3-a44e-5aba-beff-754bcfdb5268
- DOI
- 10.17638/03028185