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Research progress of drug resistance mechanism of temozolomide in the treatment of glioblastoma

31 Oct 2024

Abstract excerpt

Glioblastoma, the most malignant primary brain tumor among gliomas, is characterized by a low cure rate, high recurrence rate, and invasive growth. Without chemotherapy, the median survival of patients is only 12.1 months. The standard treatment for glioblastoma primarily involves surgical resection, complemented by radiotherapy. Temozolomide (TMZ), a new oral alkylating agent, is currently used as the first-line...

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PMID: 39568843
DOI: 10.1016/j.heliyon.2024.e39984

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