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Article

The genotypic and phenotypic impact of hypoxia microenvironment on glioblastoma cell lines.

BMC cancer - 19 Nov 2021

Macharia Lucy Wanjiku, Muriithi Wanjiru, Heming Carlos Pilotto, Nyaga Dennis Kirii, Aran Veronica, Mureithi Marianne Wanjiru, Ferrer Valeria Pereira, Pane Attilio, Filho Paulo Niemeyer, Moura-Neto Vivaldo

Abstract excerpt

BACKGROUND: Glioblastoma is a fatal brain tumour with a poor patient survival outcome. Hypoxia has been shown to reprogram cells towards a stem cell phenotype associated with self-renewal and drug resistance properties. Activation of hypoxia-inducible factors (HIFs) helps in cellular adaptation mechanisms under hypoxia. Similarly, miRNAs are known to be dysregulated in GBM have been shown to act as critical...

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Identifiers

PMID: 34798868
DOI: 10.1186/s12885-021-08978-z
PMCID: PMC8605580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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